Sunday 23rd, January 2022
canara news

Anti-body targeting fat-tissue hormone may treat diabetes

Published On : 05 Jan 2016

New York, (IANS) Researchers have found a potential new treatment for diabetes in an anti-body that they developed to target a hormone in adipose or fat tissue.

Besides Type-2 diabetes, the new therapeutic that improves glucose regulation and reduces fatty liver could potentially be used to treat fatty liver disease, and other metabolic diseases, the study said.

These monoclonal antibodies have the potential to be transformative first-in-class therapeutics to fight obesity-related metabolic and immunometabolic disease, the researchers said.

The hormone in fat tissue that the antibody targets is called aP2 (also known as FABP4).

"The importance of this study is two-fold: first, demonstrating the importance of aP2 as a critical hormone in abnormal glucose metabolism, and secondly, showing that aP2 can be effectively targeted to treat diabetes and potentially other immunometabolic diseases," said Gokhan Hotamisligil, professor at Harvard T.H. Chan School of Public Health.

The increase in adipose tissue characteristic of obesity has long been linked to increased risk for metabolic diseases such as Type-2 diabetes and cardiovascular disease.

Recently, it has become clear that the tissue itself plays an active role in metabolic disease, in part by releasing hormones which act in distant sites such as the liver, muscle, and brain that affect systemic metabolism.

In the new study, the researchers described the development and evaluation of novel monoclonal antibodies targeting the hormone aP2.

The team found that one of these antibodies effectively improved glucose regulation in two independent models of obesity.

Additionally, beneficial reductions in liver fat were observed.

This work is still at the preclinical stage and will require extensive evaluation for safety and effectiveness before being considered for use in humans, the researchers pointed out.

More News

Mother-daughter conflict ups suicide risk in abused teen girls: Study
Mother-daughter conflict ups suicide risk in abused teen girls: Study
Novel wearable ultrasound patch monitors BP inside body
Novel wearable ultrasound patch monitors BP inside body
Mental health may not ruin teenagers' friendships: Study
Mental health may not ruin teenagers' friendships: Study

Write your Comments

Disclaimer: Please write your correct name and email address. Kindly do not post any personal, abusive, defamatory, infringing, obscene, indecent, discriminatory or unlawful or similar comments. will not be responsible for any defamatory message posted under this article.

Please note that under 66A of the IT Act, sending offensive or menacing messages through electronic communication service and sending false messages to cheat, mislead or deceive people or to cause annoyance to them is punishable. It is obligatory on CANARANEWS to provide the IP address and other details of senders of such comments, to the authority concerned upon request.

Hence, sending offensive comments using canaranews will be purely at your own risk, and in no way will be held responsible.