Tuesday 17th, May 2022
canara news

Experimental drug shows promise to treat Alzheimer`s

Published On : 23 Jun 2015


New York, June 22 (IANS) An experimental drug has been found to protect Alzheimer's-inflicted mice from memory deterioration, despite a high-glycemic-index (GI) diet meant to boost blood sugar levels.

The experimental drug from the US-based Eli Lilly and Company mimics the hunger-signalling hormone ghrelin.

"The present results suggest that ghrelin might improve cognition in Alzheimer's disease via a central nervous system mechanism involving insulin signalling," authors of the study published in the journal Scientific Reports wrote.

"With chronic diseases like diabetes and Alzheimer's, you need to do a long-term study," said examiner Inga Kadish, assistant professor at University of Alabama School of Medicine at Birmingham.

"So we did an experiment with the worst-case scenario, a high-GI diet. Alzheimer's disease has 10 or 20 risk factors and some of the strongest risk factors are diabetes or metabolic syndrome."

In contrast to short-term administration of the "ghrelin agonista drug -- which impairs insulin sensitivity and glucose tolerance, which are signs of metabolic syndrome and diabetes -- the researchers found that the long-term ghrelin agonist treatment did not impair insulin signalling and glucose tolerance in Alzheimer's disease mice fed with a high GI diet.

In the study, the Alzheimer's disease-model mice showed a deterioration in spatial learning as they turned older -- in other words, they got lost when trying to swim to a platform hidden just beneath the water surface that they previously were trained to find in a four-foot-wide pool.

The test mice fed with the ghrelin agonist and the high-GI diet showed long-term cognitive enhancement in this water maze test as compared to the mice fed with a normal diet or high-GI diet only.

The test mice also showed more activity, reduced body weight and fat mass. They also showed a beneficial impact of the long-term ghrelin agonist treatment on insulin signalling pathways in hippocampal brain tissue.

Alzheimer's patients show significant shrinkage of the hippocampus, a part of the brain cortex that has a key role in forming new memories.







More News

Mother-daughter conflict ups suicide risk in abused teen girls: Study
Mother-daughter conflict ups suicide risk in abused teen girls: Study
Novel wearable ultrasound patch monitors BP inside body
Novel wearable ultrasound patch monitors BP inside body
Mental health may not ruin teenagers' friendships: Study
Mental health may not ruin teenagers' friendships: Study

Write your Comments

Disclaimer: Please write your correct name and email address. Kindly do not post any personal, abusive, defamatory, infringing, obscene, indecent, discriminatory or unlawful or similar comments. canaranews.com will not be responsible for any defamatory message posted under this article.

Please note that under 66A of the IT Act, sending offensive or menacing messages through electronic communication service and sending false messages to cheat, mislead or deceive people or to cause annoyance to them is punishable. It is obligatory on CANARANEWS to provide the IP address and other details of senders of such comments, to the authority concerned upon request.

Hence, sending offensive comments using canaranews will be purely at your own risk, and in no way will canaranews.com be held responsible.