Udupi: Researchers from the School of Life Sciences (SOLS) and Kasturba Medical College, Manipal University, have performed DNA analysis by targeted exome sequencing in long standing ulcerative colitis subjects at risk of progressing into colorectal cancer and identified cancer causing mutations in new as well as previously identified oncogenes and tumour suppressor genes.
The finding of the study is published in the British Journal of Cancer entitled “Targeted sequencing based analyses of candidate gene variants in ulcerative colitis-associated colorectal neoplasia”, which was also supported by Department of Biotechnology, Government of India.
SOLS has been working in the field of cancer biomarker discovery, disease modelling and targeted drug delivery for the past several years, according to its Director K. Satyamoorthy.
Ulcerative colitis is a chronic inflammatory bowel condition with clinical symptoms of ulceration and bleeding of inner lining of colon. The age of onset for ulcerative colitis varies between 30 to 50 in human beings. Ulcerative colitis subjects with more than seven years of pancolitis or more than 10 years of left sided colitis, experience a higher incidence of colorectal cancer than the rest of the population.
